Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-29228
Cell 1985 May 01;411:177-90.
Show Gene links Show Anatomy links

Cell type-specific expression of nuclear lamina proteins during development of Xenopus laevis.

Benavente R , Krohne G , Franke WW .


???displayArticle.abstract???
The cell type-specific expression of the major nuclear lamina polypeptides ("lamins") during development of Xenopus was studied using two monoclonal antibodies (L(0)46F7: specific for LIII, the single lamin of oocytes; PKB8: specific for LI and LII of some somatic cells). In the oocyte, LIII localizes in the nuclear polymer, but upon nuclear envelope breakdown it is solubilized to a form sedimenting at 9 S. In early embryos, LIII contributes to nuclear lamina formation until its depletion. Correspondingly, LI and LII begin to be expressed at a specific point in embryogenesis and appear to be integrated with LIII into a common lamina structure. Later in development, LIII reappears as a prominent nuclear lamina protein but only in certain cells (neurons, muscle cells, and diplotene oocytes). We conclude that amphibian lamins represent a family of proteins expressed in relation to certain programs of cell differentiation.

???displayArticle.pubmedLink??? 3888407
???displayArticle.link??? Cell


Species referenced: Xenopus laevis
Genes referenced: akt2 alb cat.1 krt12.4 lmnb3 rpsa
???displayArticle.antibodies??? Lmnb2/3 Ab5 Lmnb3 Ab4


???attribute.lit??? ???displayArticles.show???