Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
???displayArticle.abstract???
Dickkopfs (Dkks) are secreted developmental regulators composed of two cysteine-rich domains. We report that the effects of Dkks depend on molecular context. Although Wnt8 signaling is inhibited by both Dkk1 and Dkk2 in Xenopus embryos, the same pathway is activated upon interaction of Dkk2 with the Wnt coreceptor LRP6. Analysis of individual Dkk domains and chimeric Dkks shows that the carboxy-terminal domains of both Dkks associate with LRP6 and are necessary and sufficient for Wnt8 inhibition, whereas the amino-terminal domain of Dkk1 plays an inhibitory role in Dkk-LRP interactions. Our study illustrates how an inhibitor of a pathway may be converted into an activator and is the first study to suggest a molecular mechanism for how a ligand other than Wnt can positively regulate beta-catenin signaling.
Aravind,
A colipase fold in the carboxy-terminal domain of the Wnt antagonists--the Dickkopfs.
1998, Pubmed,
Xenbase
Aravind,
A colipase fold in the carboxy-terminal domain of the Wnt antagonists--the Dickkopfs.
1998,
Pubmed
,
Xenbase
Bafico,
Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow.
2001,
Pubmed
Bhanot,
A new member of the frizzled family from Drosophila functions as a Wingless receptor.
1996,
Pubmed
Bouwmeester,
Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer.
1996,
Pubmed
,
Xenbase
Brannon,
A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus.
1997,
Pubmed
,
Xenbase
Cadigan,
Wnt signaling: a common theme in animal development.
1997,
Pubmed
,
Xenbase
Chen,
High-efficiency transformation of mammalian cells by plasmid DNA.
1987,
Pubmed
Christian,
Xwnt-8, a Xenopus Wnt-1/int-1-related gene responsive to mesoderm-inducing growth factors, may play a role in ventral mesodermal patterning during embryogenesis.
1991,
Pubmed
,
Xenbase
Christian,
Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus.
1993,
Pubmed
,
Xenbase
Fan,
A role for Siamois in Spemann organizer formation.
1997,
Pubmed
,
Xenbase
Fan,
Wnt signaling and transcriptional control of Siamois in Xenopus embryos.
1998,
Pubmed
,
Xenbase
Fedi,
Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling.
1999,
Pubmed
Glinka,
Head induction by simultaneous repression of Bmp and Wnt signalling in Xenopus.
1997,
Pubmed
,
Xenbase
Glinka,
Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction.
1998,
Pubmed
,
Xenbase
Graff,
Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo.
1994,
Pubmed
,
Xenbase
Grotewold,
Expression pattern of Dkk-1 during mouse limb development.
1999,
Pubmed
,
Xenbase
Harland,
Formation and function of Spemann's organizer.
1997,
Pubmed
Hashimoto,
Zebrafish Dkk1 functions in forebrain specification and axial mesendoderm formation.
2000,
Pubmed
,
Xenbase
Hsieh,
Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein.
1999,
Pubmed
,
Xenbase
Hsieh,
A new secreted protein that binds to Wnt proteins and inhibits their activities.
1999,
Pubmed
,
Xenbase
Itoh,
Specific modulation of ectodermal cell fates in Xenopus embryos by glycogen synthase kinase.
1995,
Pubmed
,
Xenbase
Itoh,
Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and beta-catenin.
1998,
Pubmed
,
Xenbase
Kazanskaya,
The role of Xenopus dickkopf1 in prechordal plate specification and neural patterning.
2000,
Pubmed
,
Xenbase
Krupnik,
Functional and structural diversity of the human Dickkopf gene family.
1999,
Pubmed
,
Xenbase
Li,
Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled.
2002,
Pubmed
Makarova,
Generation of deletion and point mutations with one primer in a single cloning step.
2000,
Pubmed
Mao,
Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway.
2001,
Pubmed
Mao,
LDL-receptor-related protein 6 is a receptor for Dickkopf proteins.
2001,
Pubmed
,
Xenbase
Marvin,
Inhibition of Wnt activity induces heart formation from posterior mesoderm.
2001,
Pubmed
,
Xenbase
McMahon,
Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis.
1989,
Pubmed
,
Xenbase
Monaghan,
Dickkopf genes are co-ordinately expressed in mesodermal lineages.
1999,
Pubmed
,
Xenbase
Mukhopadhyay,
Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse.
2001,
Pubmed
,
Xenbase
Newport,
A major developmental transition in early Xenopus embryos: I. characterization and timing of cellular changes at the midblastula stage.
1982,
Pubmed
,
Xenbase
Peifer,
Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus.
2000,
Pubmed
Perrimon,
Specificities of heparan sulphate proteoglycans in developmental processes.
2000,
Pubmed
Pinson,
An LDL-receptor-related protein mediates Wnt signalling in mice.
2000,
Pubmed
Rattner,
A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors.
1997,
Pubmed
Sasaki,
Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling.
1999,
Pubmed
,
Xenbase
Schneider,
Wnt antagonism initiates cardiogenesis in Xenopus laevis.
2001,
Pubmed
,
Xenbase
Semënov,
Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.
2001,
Pubmed
,
Xenbase
Shinya,
Zebrafish Dkk1, induced by the pre-MBT Wnt signaling, is secreted from the prechordal plate and patterns the anterior neural plate.
2000,
Pubmed
,
Xenbase
Smith,
Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center.
1991,
Pubmed
,
Xenbase
Sokol,
Injected Wnt RNA induces a complete body axis in Xenopus embryos.
1991,
Pubmed
,
Xenbase
Suzuki,
A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo.
1994,
Pubmed
,
Xenbase
Tamai,
LDL-receptor-related proteins in Wnt signal transduction.
2000,
Pubmed
,
Xenbase
Wehrli,
arrow encodes an LDL-receptor-related protein essential for Wingless signalling.
2000,
Pubmed
Wu,
Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/beta-catenin signalling.
,
Pubmed
,
Xenbase
Xu,
Functional and biochemical interactions of Wnts with FrzA, a secreted Wnt antagonist.
1998,
Pubmed
,
Xenbase
Zorn,
Cell-cell signalling: frog frizbees.
1997,
Pubmed
,
Xenbase
