Moody SA , Neilson KM , Kenyon KL , Alfandari D , Pignoni F .

R01 DE016289 NIDCR NIH HHS, R01 DE022065 NIDCR NIH HHS, R01 EY013167 NEI NIH HHS , R03 HD055321 NICHD NIH HHS , R03HD055321 NICHD NIH HHS

Andersen, Drosophila MCRS2 associates with RNA polymerase II complexes to regulate transcription. 2010, Pubmed

Andersen, Drosophila MCRS2 associates with RNA polymerase II complexes to regulate transcription. 2010, Pubmed
Anderson, The Drosophila Wilms׳ Tumor 1-Associating Protein (WTAP) homolog is required for eye development. 2014, Pubmed
Bailey, Lens specification is the ground state of all sensory placodes, from which FGF promotes olfactory identity. 2006, Pubmed
Bajoghli, Groucho corepressor proteins regulate otic vesicle outgrowth. 2005, Pubmed
Bane, EYA1 expression in the developing inner ear. 2005, Pubmed , Xenbase
Bhattacharyya, Hierarchy of regulatory events in sensory placode development. 2004, Pubmed
Bidet, Modifiers of muscle and heart cell fate specification identified by gain-of-function screen in Drosophila. 2003, Pubmed
Birk, SOBP is mutated in syndromic and nonsyndromic intellectual disability and is highly expressed in the brain limbic system. 2010, Pubmed
Blanco, Genetic interactions of eyes absent, twin of eyeless and orthodenticle regulate sine oculis expression during ocellar development in Drosophila. 2010, Pubmed
Blanco, Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. 2010, Pubmed
Blitz, Biallelic genome modification in F(0) Xenopus tropicalis embryos using the CRISPR/Cas system. 2013, Pubmed , Xenbase
Bosman, Catweasel mice: a novel role for Six1 in sensory patch development and a model for branchio-oto-renal syndrome. 2009, Pubmed
Bricaud, Balancing cell numbers during organogenesis: Six1a differentially affects neurons and sensory hair cells in the inner ear. 2011, Pubmed
Bricaud, The transcription factor six1 inhibits neuronal and promotes hair cell fate in the developing zebrafish (Danio rerio) inner ear. 2006, Pubmed
Brodbeck, Genetic determination of nephrogenesis: the Pax/Eya/Six gene network. 2004, Pubmed
Brugmann, Six1 promotes a placodal fate within the lateral neurogenic ectoderm by functioning as both a transcriptional activator and repressor. 2004, Pubmed , Xenbase
Brugmann, Induction and specification of the vertebrate ectodermal placodes: precursors of the cranial sensory organs. 2005, Pubmed , Xenbase
Chang, Branchio-oto-renal syndrome: the mutation spectrum in EYA1 and its phenotypic consequences. 2004, Pubmed
Chen, Initiation of olfactory placode development and neurogenesis is blocked in mice lacking both Six1 and Six4. 2009, Pubmed
Chen, Jxc1/Sobp, encoding a nuclear zinc finger protein, is critical for cochlear growth, cell fate, and patterning of the organ of corti. 2008, Pubmed
Cheyette, The Drosophila sine oculis locus encodes a homeodomain-containing protein required for the development of the entire visual system. 1994, Pubmed
Christophorou, Activation of Six1 target genes is required for sensory placode formation. 2009, Pubmed
Davidovic, The nuclear microspherule protein 58 is a novel RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal mRNPs from neurons. 2006, Pubmed
Duggan, Foxg1 is required for development of the vertebrate olfactory system. 2008, Pubmed
Elepfandt, Hearing threshold and frequency discrimination in the purely aquatic frog Xenopus laevis (Pipidae): measurement by means of conditioning. 2000, Pubmed , Xenbase
Figeac, ErbB3 binding protein-1 (Ebp1) controls proliferation and myogenic differentiation of muscle stem cells. 2014, Pubmed
Fraser, Frequency of the branchio-oto-renal (BOR) syndrome in children with profound hearing loss. 1980, Pubmed
Gerber, Transcriptional activation modulated by homopolymeric glutamine and proline stretches. 1994, Pubmed
Gilchrist, From expression cloning to gene modeling: the development of Xenopus gene sequence resources. 2012, Pubmed , Xenbase
Giot, A protein interaction map of Drosophila melanogaster. 2003, Pubmed
Gocke, ZNF198 stabilizes the LSD1-CoREST-HDAC1 complex on chromatin through its MYM-type zinc fingers. 2008, Pubmed
Gray, Mouse brain organization revealed through direct genome-scale TF expression analysis. 2004, Pubmed
Grifone, Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo. 2005, Pubmed
Grocott, The peripheral sensory nervous system in the vertebrate head: a gene regulatory perspective. 2012, Pubmed
Han, Transcriptional repression by the Drosophila even-skipped protein: definition of a minimal repression domain. 1993, Pubmed
Harland, Xenopus research: metamorphosed by genetics and genomics. 2011, Pubmed , Xenbase
Hatini, Dynamics of placodal lineage development revealed by targeted transgene expression. 1999, Pubmed
Hayashi, Cell-type-specific transcription of prospero is controlled by combinatorial signaling in the Drosophila eye. 2008, Pubmed
Hellsten, The genome of the Western clawed frog Xenopus tropicalis. 2010, Pubmed , Xenbase
Hilgert, Function and expression pattern of nonsyndromic deafness genes. 2009, Pubmed
Hoskins, Transcription factor SIX5 is mutated in patients with branchio-oto-renal syndrome. 2007, Pubmed
Hsu, The 58-kda microspherule protein (MSP58) represses human telomerase reverse transcriptase (hTERT) gene expression and cell proliferation by interacting with telomerase transcriptional element-interacting factor (TEIF). 2014, Pubmed
Hwang, Foxg1 is required for proper separation and formation of sensory cristae during inner ear development. 2009, Pubmed
Ikeda, Six1 is indispensable for production of functional progenitor cells during olfactory epithelial development. 2010, Pubmed
Ikeda, Six1 is essential for early neurogenesis in the development of olfactory epithelium. 2007, Pubmed
Ikeda, Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein. 2002, Pubmed
Ito, SIX1 mutation associated with enlargement of the vestibular aqueduct in a patient with branchio-oto syndrome. 2006, Pubmed
Jusiak, Regulation of Drosophila eye development by the transcription factor Sine oculis. 2014, Pubmed
Jusiak, Genome-wide DNA binding pattern of the homeodomain transcription factor Sine oculis (So) in the developing eye of Drosophila melanogaster. 2014, Pubmed
Kawakami, Six family genes--structure and function as transcription factors and their roles in development. 2000, Pubmed
Kawauchi, Foxg1 promotes olfactory neurogenesis by antagonizing Gdf11. 2009, Pubmed
Kay, The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains. 2000, Pubmed
Kenyon, Partner specificity is essential for proper function of the SIX-type homeodomain proteins Sine oculis and Optix during fly eye development. 2005, Pubmed
Kenyon, A novel fork head gene mediates early steps during Xenopus lens formation. 1999, Pubmed , Xenbase
Kenyon, Fly SIX-type homeodomain proteins Sine oculis and Optix partner with different cofactors during eye development. 2005, Pubmed
Khatri, Expression of the Foxi2 and Foxi3 transcription factors during development of chicken sensory placodes and pharyngeal arches. 2013, Pubmed
Khokha, Xenopus white papers and resources: folding functional genomics and genetics into the frog. 2012, Pubmed , Xenbase
Kim, Negative regulation of p53 by the long isoform of ErbB3 binding protein Ebp1 in brain tumors. 2010, Pubmed
Kobayashi, The homeobox protein Six3 interacts with the Groucho corepressor and acts as a transcriptional repressor in eye and forebrain formation. 2001, Pubmed
Kochhar, SIX1 mutation screening in 247 branchio-oto-renal syndrome families: a recurrent missense mutation associated with BOR. 2008, Pubmed
Konishi, Six1 and Six4 promote survival of sensory neurons during early trigeminal gangliogenesis. 2006, Pubmed
Kowalinski, The crystal structure of Ebp1 reveals a methionine aminopeptidase fold as binding platform for multiple interactions. 2007, Pubmed
Krug, Mutation screening of the EYA1, SIX1, and SIX5 genes in a large cohort of patients harboring branchio-oto-renal syndrome calls into question the pathogenic role of SIX5 mutations. 2011, Pubmed
Laclef, Thymus, kidney and craniofacial abnormalities in Six 1 deficient mice. 2003, Pubmed
Li, EYA1 mutations associated with the branchio-oto-renal syndrome result in defective otic development in Xenopus laevis. 2010, Pubmed , Xenbase
Li, Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. 2003, Pubmed
Li, The FHA domain mediates phosphoprotein interactions. 2000, Pubmed
Liu, Ebp1 isoforms distinctively regulate cell survival and differentiation. 2006, Pubmed
Lu, The ErbB3 binding protein EBP1 regulates ErbB2 protein levels and tamoxifen sensitivity in breast cancer cells. 2011, Pubmed
Mason, STRUCTURE AND FUNCTION OF THE MIDDLE EAR APPARATUS OF THE AQUATIC FROG, XENOPUS LAEVIS. 2009, Pubmed , Xenbase
Monie, Structural insights into the transcriptional and translational roles of Ebp1. 2007, Pubmed
Moody, Transcriptional regulation of cranial sensory placode development. 2015, Pubmed
Morgan, Proline: the distribution, frequency, positioning, and common functional roles of proline and polyproline sequences in the human proteome. 2013, Pubmed
Morton, Newborn hearing screening--a silent revolution. 2006, Pubmed
Mosrati, A novel dominant mutation in SIX1, affecting a highly conserved residue, result in only auditory defects in humans. 2011, Pubmed
Nakayama, Cas9-based genome editing in Xenopus tropicalis. 2014, Pubmed , Xenbase
Nakayama, Simple and efficient CRISPR/Cas9-mediated targeted mutagenesis in Xenopus tropicalis. 2013, Pubmed , Xenbase
Neilson, Developmental expression patterns of candidate cofactors for vertebrate six family transcription factors. 2010, Pubmed , Xenbase
Nissen, Zebrafish foxi one modulates cellular responses to Fgf signaling required for the integrity of ear and jaw patterning. 2003, Pubmed
Noguchi, Audiovestibular findings in a branchio-oto syndrome patient with a SIX1 mutation. 2011, Pubmed
Ohto, Tissue and developmental distribution of Six family gene products. 1998, Pubmed
Ohto, Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya. 1999, Pubmed
Ohyama, Expression of mouse Foxi class genes in early craniofacial development. 2004, Pubmed
Ozaki, Impaired interactions between mouse Eyal harboring mutations found in patients with branchio-oto-renal syndrome and Six, Dach, and G proteins. 2002, Pubmed
Ozaki, Six1 controls patterning of the mouse otic vesicle. 2004, Pubmed
Ozaki, Six4, a putative myogenin gene regulator, is not essential for mouse embryonal development. 2001, Pubmed
Pandur, Xenopus Six1 gene is expressed in neurogenic cranial placodes and maintained in the differentiating lateral lines. 2000, Pubmed , Xenbase
Patrick, Biochemical and functional characterization of six SIX1 Branchio-oto-renal syndrome mutations. 2009, Pubmed
Patrick, Structure-function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome. 2013, Pubmed
Pauley, Foxg1 is required for morphogenesis and histogenesis of the mammalian inner ear. 2006, Pubmed
Pauli, Identification of functional sine oculis motifs in the autoregulatory element of its own gene, in the eyeless enhancer and in the signalling gene hedgehog. 2005, Pubmed
Pignoni, The eye-specification proteins So and Eya form a complex and regulate multiple steps in Drosophila eye development. 1997, Pubmed
Piñeiro, A conserved transcriptional network regulates lamina development in the Drosophila visual system. 2014, Pubmed
Powers, Probing the Xenopus laevis inner ear transcriptome for biological function. 2012, Pubmed , Xenbase
Raja, The nonspecific lethal complex is a transcriptional regulator in Drosophila. 2010, Pubmed
Ruf, SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes. 2004, Pubmed
Saint-Jeannet, Establishing the pre-placodal region and breaking it into placodes with distinct identities. 2014, Pubmed , Xenbase
Sanggaard, Branchio-oto-renal syndrome: detection of EYA1 and SIX1 mutations in five out of six Danish families by combining linkage, MLPA and sequencing analyses. 2007, Pubmed
Schlosser, Molecular anatomy of placode development in Xenopus laevis. 2004, Pubmed , Xenbase
Schlosser, Eya1 and Six1 promote neurogenesis in the cranial placodes in a SoxB1-dependent fashion. 2008, Pubmed , Xenbase
Schoffelen, Mechanics of the exceptional anuran ear. 2008, Pubmed , Xenbase
Self, Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney. 2006, Pubmed
Seo, Six class homeobox genes in drosophila belong to three distinct families and are involved in head development. 1999, Pubmed
Serikaku, sine oculis is a homeobox gene required for Drosophila visual system development. 1994, Pubmed
Shi, Downregulation of MSP58 inhibits growth of human colorectal cancer cells via regulation of the cyclin D1-cyclin-dependent kinase 4-p21 pathway. 2009, Pubmed
Silver, Functional dissection of eyes absent reveals new modes of regulation within the retinal determination gene network. 2003, Pubmed
Solomon, Expression and phylogenetic analyses of three zebrafish FoxI class genes. 2003, Pubmed
Squatrito, EBP1 is a nucleolar growth-regulating protein that is part of pre-ribosomal ribonucleoprotein complexes. 2004, Pubmed
Streit, Early development of the cranial sensory nervous system: from a common field to individual placodes. 2004, Pubmed
Sun, Poly-small ubiquitin-like modifier (PolySUMO)-binding proteins identified through a string search. 2012, Pubmed
Van Dijk, Mechanics of the frog ear. 2011, Pubmed
Wheeler, Simple vertebrate models for chemical genetics and drug discovery screens: lessons from zebrafish and Xenopus. 2009, Pubmed , Xenbase
Williamson, The structure and function of proline-rich regions in proteins. 1994, Pubmed
Wu, Downregulation of MSP58 suppresses cell proliferation in neuroblastoma cell lines. 2012, Pubmed
Xia, Ebp1, an ErbB-3 binding protein, interacts with Rb and affects Rb transcriptional regulation. 2001, Pubmed
Xu, Six1 is required for the early organogenesis of mammalian kidney. 2003, Pubmed
Xu, Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia. 1999, Pubmed
Yan, A transcriptional chain linking eye specification to terminal determination of cone cells in the Drosophila eye. 2003, Pubmed
Yan, Microarray identification of novel genes downstream of Six1, a critical factor in cranial placode, somite, and kidney development. 2015, Pubmed , Xenbase
Yoo, Interaction of the PA2G4 (EBP1) protein with ErbB-3 and regulation of this binding by heregulin. 2000, Pubmed
Zhang, Direct control of neurogenesis by selector factors in the fly eye: regulation of atonal by Ey and So. 2006, Pubmed
Zhang, Alterations in cell growth and signaling in ErbB3 binding protein-1 (Ebp1) deficient mice. 2008, Pubmed
Zheng, The role of Six1 in mammalian auditory system development. 2003, Pubmed
Zhong, Expression of MSP58 in hepatocellular carcinoma. 2013, Pubmed
Zhou, Post-transcriptional regulation of androgen receptor mRNA by an ErbB3 binding protein 1 in prostate cancer. 2010, Pubmed
Zhou, Onset of atonal expression in Drosophila retinal progenitors involves redundant and synergistic contributions of Ey/Pax6 and So binding sites within two distant enhancers. 2014, Pubmed
Zhou, EBP1 inhibits translation of androgen receptor mRNA in castration resistant prostate cancer cells. 2011, Pubmed
Zhu, Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors. 2002, Pubmed
Zou, Eya1 regulates the growth of otic epithelium and interacts with Pax2 during the development of all sensory areas in the inner ear. 2006, Pubmed
Zou, Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1. 2006, Pubmed
Zou, Eya1 and Six1 are essential for early steps of sensory neurogenesis in mammalian cranial placodes. 2004, Pubmed