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XB-ART-41958
Proc Natl Acad Sci U S A 2010 Aug 31;10735:15340-4. doi: 10.1073/pnas.1004334107.
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Highly sensitive and selective odorant sensor using living cells expressing insect olfactory receptors.

Misawa N , Mitsuno H , Kanzaki R , Takeuchi S .


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This paper describes a highly sensitive and selective chemical sensor using living cells (Xenopus laevis oocytes) within a portable fluidic device. We constructed an odorant sensor whose sensitivity is a few parts per billion in solution and can simultaneously distinguish different types of chemicals that have only a slight difference in double bond isomerism or functional group such as -OH, -CHO and -C(=O)-. We developed a semiautomatic method to install cells to the fluidic device and achieved stable and reproducible odorant sensing. In addition, we found that the sensor worked for multiple-target chemicals and can be integrated with a robotic system without any noise reduction systems. Our developed sensor is compact and easy to replace in the system. We believe that the sensor can potentially be incorporated into a portable system for monitoring environmental and physical conditions.

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References [+] :
Baumgartner, Two-microelectrode voltage clamp of Xenopus oocytes: voltage errors and compensation for local current flow. 1999, Pubmed, Xenbase