XB-ART-5110
Mol Cell
2003 Jun 01;116:1420-1. doi: 10.1016/s1097-2765(03)00233-8.
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Emi1 proteolysis: how SCF(beta-Trcp1) helps to activate the anaphase-promoting complex.
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Emi1 inhibits the anaphase-promoting complex (APC) during S and G2 phase. Two papers by Guardavaccaro et al. and Margottin-Goguet et al. in the June issue of Developmental Cell now show that Emi1 degradation in early mitosis is mediated by beta-Trcp1, an adaptor protein that recruits proteins to the SCF ubiquitin ligase.
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Species referenced: Xenopus
Genes referenced: fbxo5 tbx2
References [+] :
Guardavaccaro,
Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo.
2003, Pubmed