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XB-ART-46703
Science 2013 Mar 22;3396126:1436-41. doi: 10.1126/science.1231499.
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RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-β-catenin signaling.

Cruciat CM , Dolde C , de Groot RE , Ohkawara B , Reinhard C , Korswagen HC , Niehrs C .


Abstract
Casein kinase 1 (CK1) members play key roles in numerous biological processes. They are considered "rogue" kinases, because their enzymatic activity appears unregulated. Contrary to this notion, we have identified the DEAD-box RNA helicase DDX3 as a regulator of the Wnt-β-catenin network, where it acts as a regulatory subunit of CK1ε: In a Wnt-dependent manner, DDX3 binds CK1ε and directly stimulates its kinase activity, and promotes phosphorylation of the scaffold protein dishevelled. DDX3 is required for Wnt-β-catenin signaling in mammalian cells and during Xenopus and Caenorhabditis elegans development. The results also suggest that the kinase-stimulatory function extends to other DDX and CK1 members, opening fresh perspectives for one of the longest-studied protein kinase families.

PubMed ID: 23413191
Article link: Science


Species referenced: Xenopus
Genes referenced: csnk1a1 ctnnb1 dvl2
Morpholinos: ddx3x MO1

References [+] :
Wrighton, Cell signalling: DDX3 in command of CK1ε. 2013, Pubmed