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Development 2000 Jul 01;12713:2945-54. doi: 10.1242/dev.127.13.2945.
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The homeodomain-containing gene Xdbx inhibits neuronal differentiation in the developing embryo.

Gershon AA , Rudnick J , Kalam L , Zimmerman K .

The development of the vertebrate nervous system depends upon striking a balance between differentiating neurons and neural progenitors in the early embryo. Our findings suggest that the homeodomain-containing gene Xdbx regulates this balance by maintaining neural progenitor populations within specific regions of the neuroectoderm. In posterior regions of the Xenopus embryo, Xdbx is expressed in a bilaterally symmetric stripe that lies at the middle of the mediolateral axis of the neural plate. This stripe of Xdbx expression overlaps the expression domain of the proneural basic/helix-loop-helix-containing gene, Xash3, and is juxtaposed to the expression domains of Xenopus Neurogenin related 1 and N-tubulin, markers of early neurogenesis in the embryo. Xdbx overexpression inhibits neuronal differentiation in the embryo and when co-injected with Xash3, Xdbx inhibits the ability of Xash3 to induce ectopic neurogenesis. One role of Xdbx during normal development may therefore be to restrict spatially neuronal differentiation within the neural plate, possibly by altering the neuronal differentiation function of Xash3.

PubMed ID: 10851138
Article link: Development
Grant support: [+]

Species referenced: Xenopus
Genes referenced: ascl2 cdh20 dbx1 dbx2 egr2 en2 hlx irx3 ncam1 neurod1 neurog1 neurog2 notch1 tubb2b
GO keywords: neuron differentiation

Article Images: [+] show captions