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XB-ART-12910
Semin Cell Dev Biol 1999 Feb 01;101:85-91. doi: 10.1006/scdb.1998.0281.
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GATA transcription factors and cardiac development.

Charron F , Nemer M .


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Three members of the GATA family of transcription factors, GATA-4, -5, and -6, are expressed in the developing heart. One family member, GATA-5, is restricted to the endocardium while the other two, GATA-4 and -6, are present in the myocardium where they apparently fulfil distinct functions. The mechanisms underlying GATA factor specificity are not fully understood but may involve interaction with other tissue-restricted or ubiquitous co-factors. Thus, combinatorial interaction among GATA factors or between GATA factors and other co-factors may differentially control various stages of cardiogenesis.

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Species referenced: Xenopus
Genes referenced: gata4 gata5