XB-ART-27539
Genes Dev
1988 May 01;25:598-605. doi: 10.1101/gad.2.5.598.
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Translational inactivation of ribosomal protein mRNAs during Xenopus oocyte maturation.
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Ribosomal protein synthesis ceases upon maturation of Xenopus oocytes. We find that this cessation results from the dissociation of ribosomal protein mRNAs from polysomes and is accompanied by the deadenylation of these transcripts. A synthetic mRNA encoding ribosomal protein L1, microinjected into stage VI oocytes, is deadenylated and released from polysomes upon maturation. Our results indicate that sequences located within 387 bp of the 3' terminus of L1 mRNA direct both the deadenylation and polysomal release of this ribosomal protein mRNA. The proper translational regulation of an exogenous ribosomal protein mRNA in microinjected oocytes provides a basis for determining the sequence specificity for the differential utilization of maternal mRNAs during oocyte maturation.
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