XB-ART-39210Development 2008 Oct 01;13519:3185-90. doi: 10.1242/dev.026443.
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GATA transcription factors integrate Wnt signalling during heart development.
Cardiogenesis is inhibited by canonical Wnt/beta-catenin signalling and stimulated by non-canonical Wnt11/JNK signalling, but how these two signalling pathways crosstalk is currently unknown. Here, we show that Wnt/beta-catenin signalling restricts cardiogenesis via inhibition of GATA gene expression, as experimentally reinstating GATA function overrides beta-catenin-mediated inhibition and restores cardiogenesis. Furthermore, we show that GATA transcription factors in turn directly regulate Wnt11 gene expression, and that Wnt11 is required to a significant degree for mediating the cardiogenesis-promoting function of GATA transcription factors. These results demonstrate that GATA factors occupy a central position between canonical and non-canonical Wnt signalling in regulating heart muscle formation.
PubMed ID: 18715946
Article link: Development
Species referenced: Xenopus
Genes referenced: gata4 gata6 myh6 myl2 tnni3 wnt11
Morpholinos: wnt11b MO1
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