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XB-ART-2674
Science 2004 Nov 26;3065701:1571-3. doi: 10.1126/science.1103124.
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Nucleosome arrays reveal the two-start organization of the chromatin fiber.

Dorigo B , Schalch T , Kulangara A , Duda S , Schroeder RR , Richmond TJ .


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Chromatin folding determines the accessibility of DNA constituting eukaryotic genomes and consequently is profoundly important in the mechanisms of nuclear processes such as gene regulation. Nucleosome arrays compact to form a 30-nanometer chromatin fiber of hitherto disputed structure. Two competing classes of models have been proposed in which nucleosomes are either arranged linearly in a one-start higher order helix or zigzag back and forth in a two-start helix. We analyzed compacted nucleosome arrays stabilized by introduction of disulfide cross-links and show that the chromatin fiber comprises two stacks of nucleosomes in accord with the two-start model.

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References :
Mohd-Sarip, Molecular biology. A higher order of silence. 2004, Pubmed