XB-ART-36546
Biochem Biophys Res Commun
2007 Sep 14;3611:214-7. doi: 10.1016/j.bbrc.2007.07.009.
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TRPV1 as a key determinant in ciguatera and neurotoxic shellfish poisoning.
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Ciguatera fish poisoning and neurotoxic shellfish poisoning are distinct clinical entities characterized by gastrointestinal and neurological disturbances, following the consumption of certain reef fish and shellfish containing toxic polyether compounds sporadically present in certain toxic marine dinoflagellates. The biotransformation and bioaccumulation of gambierol and brevetoxin, and their congeners, are believed to be involved in the pathogenesis of these "food-chain diseases", for which no effective treatments are available. Here, we describe for the first time the potent effect of gambierol and brevetoxin on TRPV1 channels, a key player in thermal and pain sensation. Our findings may lead to promising new therapeutic interventions.
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Species referenced: Xenopus laevis
Genes referenced: trpv1
References [+] :
Cameron,
The basis of the paradoxical disturbance of temperature perception in ciguatera poisoning.
1993, Pubmed