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XB-ART-53379
Org Biomol Chem 2016 Jan 21;143:835-9. doi: 10.1039/c5ob02323h.
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Semisynthetic UbH2A reveals different activities of deubiquitinases and inhibitory effects of H2A K119 ubiquitination on H3K36 methylation in mononucleosomes.

Bi X , Yang R , Feng X , Rhodes D , Liu CF .


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Using a genetically incorporated azidonorleucine for ubiquitin installation, we prepared multi-milligram quantities of H2AK119ub (ubH2A). With a native isopeptide linkage, the synthetic ubH2A was used to study the activity of deubiquitinases and crosstalk between H2A ubiquitination and H3K36 methylation in the context of chemically defined mononucleosomes.

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Species referenced: Xenopus laevis
Genes referenced: h2ac21