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Mol Reprod Dev 2001 Nov 01;603:331-7. doi: 10.1002/mrd.1095.
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Distinct roles for Distal-less genes Dlx3 and Dlx5 in regulating ectodermal development in Xenopus.

Luo T , Matsuo-Takasaki M , Sargent TD .

In vertebrates, there are six or more copies of genes related to the Drosophila pattern formation homeodomain gene Distal-less. Among this family, Dlx3 and Dlx5 share extensive sequence homology and have similar, but distinctive, expression patterns, suggesting that these two factors may have substantially redundant developmental functions. Here we show that at the earliest phases of embryogenesis in Xenopus, there are significant differences between Dlx3 and Dlx5 expression and that this correlates with different functions in the restriction of neural crest and neural plate boundaries, respectively.

PubMed ID: 11599044
Article link: Mol Reprod Dev

Species referenced: Xenopus laevis
Genes referenced: dlx3 dlx5