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Mol Cell Biol
1989 Jan 01;91:336-41. doi: 10.1128/mcb.9.1.336-341.1989.
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Electron microscopy reveals that transcription factor TFIIIA bends 5S DNA.
Bazett-Jones DP
,
Brown ML
.
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We have used a high-resolution analytical electron microscopic technique, electron spectroscopic imaging, to study the in vitro interaction between the transcription factor IIIA (TFIIIA) and 5S ribosomal gene DNA. The images and analytical measurements support our proposal that the helix axis is bent by the protein into a hairpin-shaped configuration.
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