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XB-ART-24924
Nature 1991 Apr 04;3506317:398-402. doi: 10.1038/350398a0.
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Primary structure and functional expression from complementary DNA of a brain calcium channel.

Mori Y , Friedrich T , Kim MS , Mikami A , Nakai J , Ruth P , Bosse E , Hofmann F , Flockerzi V , Furuichi T .


Abstract
The primary structure of a voltage-dependent calcium channel from rabbit brain has been deduced by cloning and sequencing the complementary DNA. Calcium channel activity expressed from the cDNA is dramatically increased by coexpression of the alpha 2 and beta subunits, known to be associated with the dihydropyridine receptor. This channel is a high voltage-activated calcium channel that is insensitive both to nifedipine and to omega-conotoxin. We suggest that it is expressed predominantly in cerebellar Purkinje cells and granule cells.

PubMed ID: 1849233
Article link: Nature