Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Xenopus laevis 19S immunoglobulin. Ultrastructure and J chain isolation.
Hadji-Azimi I
,
Michea-Hamzehpour M
.
???displayArticle.abstract???
Electron microscopy examination of the 19S immunoglobulin of Xenopus laevis revealed a hexameric structure with a central core. The molecules measured 360-430 A across the span of the arms and the average diameter of the central region was 140 A. A polypeptide, homologous to human J chain, was isolated by chromatography on DEAE-cellulose from the reduced and alkylated X. laevis hexameric macroglobulin. This polypeptide had a fast mobility in alkaline-urea gel electrophoresis, with distinct antigenicity, as compared to heavy and light chains. It shared common antigenic determinants with human J chain.
Chapuis,
Mechanism of IgM polymerization.
1974, Pubmed
Chapuis,
Mechanism of IgM polymerization.
1974,
Pubmed
Hadji-Azimi,
Studies on Xenopus laevis immunoglobulins.
1971,
Pubmed
,
Xenbase
Hadji-Azimi,
Structural studies of the Xenopus 19S immunoglobulin and 7S immunoglobulin and two immunoglobulin-like proteins.
1975,
Pubmed
,
Xenbase
Halpern,
Noval subunit in secretory IgA.
1970,
Pubmed
Kehoe,
Identification of "J" chain in a homogeneous canine IgA immunoglobulin.
1972,
Pubmed
Kobayashi,
Identification of J-chain in polymeric immunoglobulins from a variety of species by cross-reaction with rabbit antisera to human J-chain.
1973,
Pubmed
Mendez,
Structure of immunoglobulin A. Amino acid sequence of cysteine-containing peptides from the J chain.
1973,
Pubmed
Mestecky,
Site of attachment of J chain to human immunoglobulin M.
1974,
Pubmed
Mestecky,
Immunoglobulin M and secretory immunoglobulin A: presence of a common polypeptide chain different from light chains.
1971,
Pubmed
O'Daly,
Chemical and physicochemical studies of the component polypeptide chains of rabbit secretory immunoglobulin A.
1971,
Pubmed
Parkhouse,
Biosynthesis of immunoglobulin A (IgA) and immunoglobulin M (IgM). Control of polymerization by J chain.
1973,
Pubmed
Parkhouse,
Electron microscopic studies of mouse immunoglobulin M; structure and reconstitution following reduction.
1970,
Pubmed
Reisfeld,
Electrophoretic heterogeneity of polypeptide chains of specific antibodies.
1966,
Pubmed
Shelton,
Ultrastructure of the gamma M immunoglobulin-molecule.
1970,
Pubmed
Shelton,
The ultrastructure of carp (Cyprinus carpio) immunoglobulin: a tetrameric macroglobulin.
1970,
Pubmed