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XB-ART-22562
Neuron 1993 Jun 01;106:1131-40. doi: 10.1016/0896-6273(93)90061-u.
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Argiotoxin detects molecular differences in AMPA receptor channels.

Herlitze S , Raditsch M , Ruppersberg JP , Jahn W , Monyer H , Schoepfer R , Witzemann V .


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Argiotoxin, a component of the spider venom from Argiope lobata, blocks AMPA receptor channels expressed in homomeric and heteromeric configuration in Xenopus oocytes. Argiotoxin acts as an open channel blocker in a voltage-dependent manner and discriminates between the functionally diverse AMPA receptors. Importantly, a transmembrane region 2 determinant for divalent cation permeability also determines argiotoxin sensitivity. Subunit-specific differences in the time courses of block and recovery demonstrate that heteromeric AMPA receptors can assemble in variable ratios. Thus, argiotoxin can be used as a tool in analyzing the subunit composition of AMPA receptors in native membranes.

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