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Proc Natl Acad Sci U S A 2005 Aug 30;10235:12455-8. doi: 10.1073/pnas.0505989102.
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Thyroid hormone controls multiple independent programs required for limb development in Xenopus laevis metamorphosis.

Brown DD , Cai L , Das B , Marsh-Armstrong N , Schreiber AM , Juste R .

Thyroid hormone (TH) is required for limb development in Xenopus laevis. Specific cell types in the growing limb were targeted for expression of a dominant negative form of the TH receptor by sperm-mediated transgenesis. Limb muscle development, the innervation of muscle from the spinal cord, and cartilage growth can be inhibited without affecting patterning of the limb or differentiation of other cell types. Remodeling of the skin occurs late in metamorphosis after the limb has formed. The coordination of these independent programs is affected in part by the control that TH exerts over DNA replication in all cell types of the limb.

PubMed ID: 16129821
PMC ID: PMC1194953
Article link: Proc Natl Acad Sci U S A

Species referenced: Xenopus laevis
Genes referenced: actl6a ccnd2 krt12.5 krt78.6 trdn
Phenotypes: Xla Wt + methimazole (Fig 1. row 2, column 2) [+]

Article Images: [+] show captions
References [+] :
Berry, The expression pattern of thyroid hormone response genes in the tadpole tail identifies multiple resorption programs. 1998, Pubmed, Xenbase