Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-23375
Cell 1992 Sep 04;705:829-40.
Show Gene links Show Anatomy links

Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos.



???displayArticle.abstract???
We have cloned a cDNA encoding a novel polypeptide capable of inducing dorsal development in Xenopus embryos. RNA transcripts from this clone rescue normal development when injected into ventralized embryos and result in excessive head development at high doses. Therefore, we have named the cDNA noggin, noggin cDNA contains a single reading frame encoding a 26 kd protein with a hydrophobic amino-terminal sequence, suggesting that it is secreted. In Northern blot analysis this cDNA hybridizes to two mRNAs that are expressed both maternally and zygotically. Although noggin transcript is not localized in the oocyte and cleavage stage embryo, zygotic transcripts are initially restricted to the presumptive dorsal mesoderm and reach their highest levels at the gastrula stage in the dorsal lip of the blastopore (Spemann organizer). In the neurula, noggin is transcribed in the notochord and prechordal mesoderm. The activity of exogenous noggin RNA in embryonic axis induction and the localized expression of endogenous noggin transcripts suggest that noggin plays a role in normal dorsal development.

???displayArticle.pubmedLink??? 1339313
???displayArticle.link??? Cell


Species referenced: Xenopus laevis
Genes referenced: eef1a1 nog sms wnt8a


???attribute.lit??? ???displayArticles.show???
References :
Piccolo, Fearlessly tackling the organizer. 2011, Pubmed