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G3 (Bethesda) 2016 Nov 08;611:3625-3633. doi: 10.1534/g3.116.033423.
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Sequential Turnovers of Sex Chromosomes in African Clawed Frogs (Xenopus) Suggest Some Genomic Regions Are Good at Sex Determination.

Furman BLS , Evans BJ .

Sexual differentiation is fundamentally important for reproduction, yet the genetic triggers of this developmental process can vary, even between closely related species. Recent studies have uncovered, for example, variation in the genetic triggers for sexual differentiation within and between species of African clawed frogs (genus Xenopus). Here, we extend these discoveries by demonstrating that yet another sex determination system exists in Xenopus, specifically in the species Xenopus borealis This system evolved recently in an ancestor of X. borealis that had the same sex determination system as X. laevis, a system which itself is newly evolved. Strikingly, the genomic region carrying the sex determination factor in X. borealis is homologous to that of therian mammals, including humans. Our results offer insights into how the genetic underpinnings of conserved phenotypes evolve, and suggest an important role for cooption of genetic building blocks with conserved developmental roles.

PubMed ID: 27605520
PMC ID: PMC5100861
Article link: G3 (Bethesda)

Species referenced: Xenopus
Genes referenced: dm-w

Article Images: [+] show captions
References [+] :
Adolfsson, Lack of dosage compensation accompanies the arrested stage of sex chromosome evolution in ostriches. 2013, Pubmed