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XB-ART-60103
Dev Growth Differ 1981 Jan 01;236:579-587. doi: 10.1111/j.1440-169X.1981.00579.x.
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Demonstration of rRNA Synthesis in Pre-Gastrular Embryos of Xenopus Laevis.

Shiokawa K , Misumi Y , Yamana K .


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Isolated cells from Xenopus laevis embryos at various developmental stages were incubated with (methyl-3 H) methionine to label newly synthesized RNAs. Methylation of RNAs was studied by analyzing nuclease-digests of high-molecular-weight RNAs by DEAE-Sephadex column chromatography. Labeled rRNA, mRNA and 4s RNA were distinguished by their characteristic patterns of 2'-0-methylation and base-methylation. It was concluded that rRNA synthesis starts during the mid- to late-blastula stage. This is about 4 hr, or at least 3 cell cycles earlier than the initiation of gastrulation, which was previously considered to be the stage when rRNA synthesis begins.

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