Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-22078
Science 1993 Oct 29;2625134:713-8.
Show Gene links Show Anatomy links

Neural induction by the secreted polypeptide noggin.

Lamb TM , Knecht AK , Smith WC , Stachel SE , Economides AN , Stahl N , Yancopolous GD , Harland RM .


???displayArticle.abstract???
The Spermann organizer induces neural tissue from dorsal ectoderm and dorsalizes lateral and ventral mesoderm in Xenopus. The secreted factor noggin, which is expressed in the organizer, can mimic the dorsalizing signal of the organizer. Data are presented showing that noggin directly induces neural tissue, that it induces neural tissue in the absence of dorsal mesoderm, and that it acts at the appropriate stage to be an endogenous neural inducing signal. Noggin induces cement glands and anterior brain markers, but not hindbrain or spinal cord markers. Thus, noggin has the expression pattern and activity expected of an endogenous neural inducer.

???displayArticle.pubmedLink??? 8235591
???displayArticle.link??? Science


Species referenced: Xenopus
Genes referenced: nog otx2
???displayArticle.antibodies??? Lsamp Ab1

References :
Barinaga, New protein appears to be long-sought neural inducer. 1993, Pubmed