Cell Differ 1986 Sep 01;192:97-101. doi: 10.1016/0045-6039(86)90066-7.

Covalent coupling of neuralizing factors from Xenopus to Sepharose beads: no decrease of inducing activity.

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Two neural inducing factors extracted from Xenopus gastrulae, a basic protein from ribonucleoprotein particles and an acidic protein from the high speed supernatant were covalently bound to CNBr-Sepharose or cross-linked CNBr-Sepharose particles. The protein-Sepharose complexes cannot be taken up by the competent ectoderm cells, but both factors remain fully active. The inducing activity is not due to a release of the bound factors. The experiments suggest that both neural inducing factors act on the cell surface of the competent ectoderm cells.

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