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Biophys J 1994 Jan 01;661:149-52.
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Low single channel conductance of the major skeletal muscle chloride channel, ClC-1.

Pusch M , Steinmeyer K , Jentsch TJ .

We expressed the skeletal muscle chloride channel, ClC-1, in HEK293 cells and investigated it with the patch-clamp technique. Macroscopic properties are similar to those obtained after expression in Xenopus oocytes, except that faster gating kinetics are observed in mammalian cells. Nonstationary noise analysis revealed that both rat and human ClC-1 have a low single channel conductance of about 1 pS. This finding may explain the lack of single-channel data for chloride channels from skeletal muscle despite its high macroscopic chloride conductance.

PubMed ID: 8130334
PMC ID: PMC1275674
Article link: Biophys J

Species referenced: Xenopus
Genes referenced: clcn1

References [+] :
Bauer, Completely functional double-barreled chloride channel expressed from a single Torpedo cDNA. 1991, Pubmed, Xenbase