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XB-ART-23284
Nature 1992 Oct 15;3596396:609-14. doi: 10.1038/359609a0.
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A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos.

Hemmati-Brivanlou A , Melton DA .


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Activins can induce mesoderm in embryonic explants and have been proposed as the natural inducer in Xenopus. A mutant activin receptor that inhibits activin signalling is used to show that activin is required for the induction of mesoderm in vivo and the patterning of the embryonic body plan. Blocking the activin signal transduction pathway also reveals autonomous induction of a neural marker and unmasks a relationship between activin and fibroblast growth factor.

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Species referenced: Xenopus laevis
Genes referenced: acvr2a acvr2b ag1 ncam1 tbxt

References :
Lemaire, Activins. No muscles, but what a brain. 1992, Pubmed, Xenbase