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Dev Genes Evol 2000 Nov 01;21011:579-81. doi: 10.1007/s004270000098.
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Xnkx-2.1: a homeobox gene expressed during early forebrain, lung and thyroid development in Xenopus laevis.

Nkx-2.1 is a member of the vertebrate Nkx family of homeobox genes; it was originally identified as a tissue-specific regulator of thyroglobulin and thyroperoxidase gene transcription. Here we report on the embryonic expression of Xnkx-2.1, which is expressed in the presumptive forebrain from early neurulation onwards. In tadpole stage embryos Xnkx-2.1 transcripts are primarily detected in ventral forebrain, lung buds and thyroid anlage. Therefore, Xnkx-2.1 may be part of the genetic network that controls the early development of these organs.

PubMed ID: 11180810
Article link: Dev Genes Evol

Species referenced: Xenopus laevis
Genes referenced: nkx2-1 nkx2-2 nkx2-3 nkx2-4 nkx2-5 nkx2-6