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XB-ART-2043
Cell 2005 Apr 08;1211:2-4. doi: 10.1016/j.cell.2005.03.017.
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Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling.

Datto M , Wang XF .


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Effects of the cytokine TGF-beta can be dampened by E3 ubiquitin ligases that target specific Smads, the TGF-beta signal transducers, for proteolytic destruction. Two papers in this issue of Cell highlight the importance of this mechanism in regulating the in vivo effects of TGF-beta. The first paper identifies and characterizes a novel Smad4 ubiquitin ligase, and the second paper redefines the role of a previously identified Smad1 ubiquitin ligase, Smurf-1 (Dupont et al., 2005; Yamashita et al., 2005).

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Species referenced: Xenopus
Genes referenced: smad1 smad10 smad4 tbx2 tgfb1

References [+] :
Dupont, Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase. 2005, Pubmed, Xenbase