Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-36479
Dev Cell 2007 Aug 01;132:166-7. doi: 10.1016/j.devcel.2007.07.015.
Show Gene links Show Anatomy links

Messages in the matrix: proteoglycans go the distance.

Gallagher J .


???displayArticle.abstract???
The fibroblast growth factors (FGFs) are key regulators of cell growth and differentiation during embryogenesis. They deliver both short-range and distant signals assisted by their proteoglycan (PG) coreceptors in the pericellular matrix. The study by Hou et al. (2007) has identified a novel autoinductive loop involving FGF and the secreted serine protease xHtrA1 that leads to the mobilization of latent FGF/PG complexes. These complexes are long-range messages for mesoderm induction and establishment of the embryonic body plan.

???displayArticle.pubmedLink??? 17681128
???displayArticle.link??? Dev Cell


Species referenced: Xenopus laevis
Genes referenced: gnao1 htra1 tbx2

References :
Hou, The secreted serine protease xHtrA1 stimulates long-range FGF signaling in the early Xenopus embryo. 2007, Pubmed, Xenbase