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J Cell Biol 2011 Oct 03;1951:19-26. doi: 10.1083/jcb.201106110.
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Actin and microtubules drive differential aspects of planar cell polarity in multiciliated cells.

Werner ME , Hwang P , Huisman F , Taborek P , Yu CC , Mitchell BJ .

Planar cell polarization represents the ability of cells to orient within the plane of a tissue orthogonal to the apical basal axis. The proper polarized function of multiciliated cells requires the coordination of cilia spacing and cilia polarity as well as the timing of cilia beating during metachronal synchrony. The planar cell polarity pathway and hydrodynamic forces have been shown to instruct cilia polarity. In this paper, we show how intracellular effectors interpret polarity to organize cellular morphology in accordance with asymmetric cellular function. We observe that both cellular actin and microtubule networks undergo drastic reorganization, providing differential roles during the polarized organization of cilia. Using computational angular correlation analysis of cilia orientation, we report a graded cellular organization downstream of cell polarity cues. Actin dynamics are required for proper cilia spacing, global coordination of cilia polarity, and coordination of metachronic cilia beating, whereas cytoplasmic microtubule dynamics are required for local coordination of polarity between neighboring cilia.

PubMed ID: 21949415
PMC ID: PMC3187709
Article link: J Cell Biol
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: actl6a clip1 noct

Article Images: [+] show captions
References [+] :
Bershteyn, MIM and cortactin antagonism regulates ciliogenesis and hedgehog signaling. 2010, Pubmed