Science 1992 Jun 12;2565063:1555-60. doi: 10.1126/science.1350865.

Early stages of motor neuron differentiation revealed by expression of homeobox gene Islet-1.

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Motor neurons in the embryonic chick spinal cord express a homeobox gene, Islet-1, soon after their final mitotic division and before the appearance of other differentiated motor neuron properties. The expression of Islet-1 by neural cells is regulated by inductive signals from the floor plate and notochord. These results establish Islet-1 as the earliest marker of developing motor neurons. The molecular nature of the Islet-1 protein suggests that it may be involved in the establishment of motor neuron fate.

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