Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-12066
J Biochem 1999 Nov 01;1265:912-6.
Show Gene links Show Anatomy links

Stage-specific inhibition of Xenopus embryogenesis by aprotinin, a serine protease inhibitor.

Iijima R , Yamaguchi S , Homma K , Natori S .


???displayArticle.abstract???
We examined the effects of various protease inhibitors on Xenopus laevis embryogenesis. Aprotinin, a serine protease inhibitor, was found to inhibit embryogenesis markedly, but other protease inhibitors had virtually no effect. The inhibitory effect of aprotinin was specific for embryos at the blastula or gastrula stage. These results suggest that an aprotinin-sensitive protease involved in embryonic development is secreted from the embryos or appears on the surface of embryonic cells at these stages. We found that various serine proteases are in fact secreted from the embryos with their development and that some of them are sensitive to aprotinin.

???displayArticle.pubmedLink??? 10544285
???displayArticle.link??? J Biochem