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XB-ART-2860
Mol Biol Cell 2005 Jan 01;161:193-201. doi: 10.1091/mbc.e04-08-0758.
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Anillin binds nonmuscle myosin II and regulates the contractile ring.



Abstract
We demonstrate that the contractile ring protein anillin interacts directly with nonmuscle myosin II and that this interaction is regulated by myosin light chain phosphorylation. We show that despite their interaction, anillin and myosin II are independently targeted to the contractile ring. Depletion of anillin in Drosophila or human cultured cells results in cytokinesis failure. Human cells depleted for anillin fail to properly regulate contraction by myosin II late in cytokinesis and fail in abscission. We propose a role for anillin in spatially regulating the contractile activity of myosin II during cytokinesis.

PubMed ID: 15496454
PMC ID: PMC539163
Article link: Mol Biol Cell
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: actl6a anln myh10 myh2 mylkl
Antibodies: Anln Ab1


Article Images: [+] show captions
References [+] :
Amano, Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). 1996, Pubmed