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XB-ART-5810
Proc Natl Acad Sci U S A 2003 Feb 18;1004:1769-74. doi: 10.1073/pnas.252774999.
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Tadpole skin dies autonomously in response to thyroid hormone at metamorphosis.

Schreiber AM , Brown DD .


Abstract
Transgenic tadpoles that express a dominant negative thyroid hormone (TH) receptor specifically in their skin undergo normal metamorphosis, with one exception: they retain a larval epidermis over the developing adult epithelium. TH-induced death of the tadpole epidermis is inhibited by the dominant negative TH receptor whereas the TH-induced response of the neighboring fibroblasts and the cells that form the adult skin occur normally. Therefore death of the tadpole skin is a direct and cell autonomous target of TH, and its protection has no detectable influence on TH-induced changes of other cell types.

PubMed ID: 12560472
PMC ID: PMC149908
Article link: Proc Natl Acad Sci U S A


Species referenced: Xenopus laevis
Genes referenced: dan4l thdl20 trdn


Article Images: [+] show captions
References [+] :
Berry, The expression pattern of thyroid hormone response genes in the tadpole tail identifies multiple resorption programs. 1998, Pubmed, Xenbase