Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-12058
Dev Biol 1999 Nov 15;2152:243-52. doi: 10.1006/dbio.1999.9481.
Show Gene links Show Anatomy links

Novel structural elements identified during tail resorption in Xenopus laevis metamorphosis: lessons from tailed frogs.

Elinson RP , Remo B , Brown DD .


Abstract
When the tail of the Xenopus laevis tadpole resorbs at the end of metamorphosis, various cell types, including muscle, fibroblasts, skin, and spinal cord, are lost at about the same time. However, feeding frogs with tails can be produced by inhibiting thyroid hormone production at the climax of metamorphosis with the goitrogen methimazole. These tails lose their fast muscle preferentially, showing that the different cell types of the tail have different fates and confirming that more than one cell death program is involved in tail resorption. Both normal and methimazole tails contain "cords," novel structures that consist of two dorsal and two ventral parallel rows of slow muscle bundles joined by collagen fibers that run the length of the tail. The cords persist until the very end of tail resorption, being the last structure to dissolve. When thyroid hormone induces expression of proteolytic enzymes in the notochord sheath, the notochord, a structural rod that runs the length of the tail, begins to buckle, demonstrating that the tail is under tension. When sections of the tail that contain cords are surgically separated from the notochord, they contract in vitro, suggesting that the cords contribute to the tension that augments tail resorption.

PubMed ID: 10545234
Article link: Dev Biol


Species referenced: Xenopus laevis
Antibodies: Fast Skeletal Muscle Ab1 Slow Skeletal Muscle Ab1


Article Images: [+] show captions