XB-ART-35868
FEBS J
2007 Mar 01;2746:1374-82. doi: 10.1111/j.1742-4658.2007.05696.x.
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What MAN1 does to the Smads. TGFbeta/BMP signaling and the nuclear envelope.
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The inner nuclear membrane protein MAN1 has been identified as an important factor in transforming growth factor beta/bone morphogenic protein (TGFbeta/BMP) signaling. Loss of MAN1 results in three autosomal dominant diseases in humans; all three characterized by increased bone density. Xenopus embryos lacking MAN1 develop severe morphological defects. Both in humans and in Xenopus embryos the defects originate from deregulation of TGFbeta/BMP signaling. Several independent studies have shown that MAN1 is antagonizing TGFbeta/BMP signaling through binding to regulatory Smads. Here, recent progress in understanding MAN1 functions is summarized and a model for MAN1-dependent regulation of TGFbeta/BMP signaling is proposed.
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Species referenced: Xenopus
Genes referenced: lemd3 tgfb1