XB-ART-4764
Trends Neurosci
2003 Sep 01;269:453-5. doi: 10.1016/S0166-2236(03)00212-1.
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Dishevelled: linking convergent extension with neural tube closure.
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Neural tube closure fails in both mouse and Xenopus when dishevelled and other components of the planar-cell-polarity pathway are misregulated. The underlying defect involves a failure of convergent extension in the midline of the early neural plate. Although bilateral neural folds form, they are abnormally far apart and cannot achieve the apposition necessary for neural tube closure.
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Species referenced: Xenopus
Genes referenced: dvl2