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XB-ART-39335
Front Biosci (Landmark Ed) 2009 Jan 01;141:167-76. doi: 10.2741/3238.
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Tumorigenesis and anti-tumor immune responses in Xenopus.

Goyos A , Robert J .


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Despite intense study, the role of the immune system in detecting (immunosurveillance), controlling and remodeling (immunoediting) neoplasia remains elusive. We present here a comparative view of the complex interactions between neoplasia and the host immune system. We provide evidence, in the amphibian Xenopus laevis, consistent with an evolutionarily conserved and crucial role of the immune system in controlling neoplasia, which involves a striking variety of anti-tumoral immune effectors including conventional CTLs, classical MHC class Ia unrestricted CTLs (CCU-CTLs) that interact with nonclassical MHC class Ib molecules, CD8 NKT-like cells and NK cells. We also review the tumors found in X. laevis with an emphasis on thymic lymphoid tumors and a rare ovarian dysgerminoma. Finally, we consider the use of X. laevis for in vivo study of tumorigenesis. Given our current knowledge, the experimental systems already established in X. laevis, and the rapid accumulation of genetic resources for the sister species Silurana (Xenopus) tropicalis, it is our conviction that these species provide an ideal alternative to the murine system for studying tumorigenesis and tumor immunity.

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Species referenced: Xenopus tropicalis Xenopus laevis
Genes referenced: cd8a mhc1a myh6 slc22a6

References [+] :
Anders, Etiology of cancer as studied in the platyfish-swordtail system. 1978, Pubmed