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XB-ART-2767
Nat Immunol 2004 Dec 01;512:1275-81. doi: 10.1038/ni1137.
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An evolutionarily conserved target motif for immunoglobulin class-switch recombination.

Zarrin AA , Alt FW , Chaudhuri J , Stokes N , Kaushal D , Du Pasquier L , Tian M .


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Immunoglobulin H class-switch recombination (CSR) occurs between switch regions and requires transcription and activation-induced cytidine deaminase (AID). Transcription through mammalian switch regions, because of their GC-rich composition, generates stable R-loops, which provide single-stranded DNA substrates for AID. However, we show here that the Xenopus laevis switch region S(mu), which is rich in AT and not prone to form R-loops, can functionally replace a mouse switch region to mediate CSR in vivo. X. laevis S(mu)-mediated CSR occurred mostly in a region of AGCT repeats targeted by the AID-replication protein A complex when transcribed in vitro. We propose that AGCT is a primordial CSR motif that targets AID through a non-R-loop mechanism involving an AID-replication protein A complex.

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Species referenced: Xenopus laevis
Genes referenced: cda

References :
Kenter, AID: a very old motif newly recognized. 2004, Pubmed