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Development 2015 May 01;1429:1555-60. doi: 10.1242/dev.121590.
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Animal models for studying neural crest development: is the mouse different?

Barriga EH , Trainor PA , Bronner M , Mayor R .

The neural crest is a uniquely vertebrate cell type and has been well studied in a number of model systems. Zebrafish, Xenopus and chick embryos largely show consistent requirements for specific genes in early steps of neural crest development. By contrast, knockouts of homologous genes in the mouse often do not exhibit comparable early neural crest phenotypes. In this Spotlight article, we discuss these species-specific differences, suggest possible explanations for the divergent phenotypes in mouse and urge the community to consider these issues and the need for further research in complementary systems.

PubMed ID: 25922521
PMC ID: PMC6514397
Article link: Development
Grant support: [+]

References [+] :
Akiyama, Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa. 2004, Pubmed