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Dev Cell 2010 Aug 17;192:345-52. doi: 10.1016/j.devcel.2010.07.012.
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ADAM13 induces cranial neural crest by cleaving class B Ephrins and regulating Wnt signaling.

Wei S , Xu G , Bridges LC , Williams P , White JM , DeSimone DW .

The cranial neural crest (CNC) consists of multipotent embryonic cells that contribute to craniofacial structures and other cells and tissues of the vertebrate head. During embryogenesis, CNC is induced at the neural plate boundary through the interplay of several major signaling pathways. Here, we report that the metalloproteinase activity of ADAM13 is required for early induction of CNC in Xenopus. In both cultured cells and X. tropicalis embryos, membrane-bound Ephrins (Efns) B1 and B2 were identified as substrates for ADAM13. ADAM13 upregulates canonical Wnt signaling and early expression of the transcription factor snail2, whereas EfnB1 inhibits the canonical Wnt pathway and snail2 expression. We propose that by cleaving class B Efns, ADAM13 promotes canonical Wnt signaling and early CNC induction.

PubMed ID: 20708595
PMC ID: PMC2951023
Article link: Dev Cell
Grant support: [+]

Species referenced: Xenopus
Genes referenced: actl6a adam13 adam19 efnb1 efnb2 gal.2 gnl3 myc snai2 sox9 wnt8a

Article Images: [+] show captions
References [+] :
Adams, The cytoplasmic domain of the ligand ephrinB2 is required for vascular morphogenesis but not cranial neural crest migration. 2001, Pubmed