Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-20960
J Cell Biol 1994 Aug 01;1263:591-601.
Show Gene links Show Anatomy links

Remodeling sperm chromatin in Xenopus laevis egg extracts: the role of core histone phosphorylation and linker histone B4 in chromatin assembly.

Dimitrov S , Dasso MC , Wolffe AP .


???displayArticle.abstract???
We find that the remodeling of the condensed Xenopus laevis sperm nucleus into the paternal pronucleus in egg extracts is associated with phosphorylation of the core histones H2A, H2A.X and H4, and uptake of a linker histone B4 and a HMG 2 protein. Histone B4 is required for the assembly of chromatosome structures in the pronucleus. However neither B4 nor core histone phosphorylation are required for the assembly of spaced nucleosomal arrays. We suggest that the spacing of nucleosomal arrays is determined by interaction between adjacent histone octamers under physiological assembly conditions.

???displayArticle.pubmedLink??? 8045925
???displayArticle.pmcLink??? PMC2120139



Species referenced: Xenopus laevis
Genes referenced: h2ac21 h2ax

References [+] :
Abé, Differentiation of spermatogenic cells from vertebrates in vitro. 1987, Pubmed