XB-ART-28192
J Microsc
1987 Apr 01;146Pt 1:29-39. doi: 10.1111/j.1365-2818.1987.tb01324.x.
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Scanning acoustic microscopy visualizes cytomechanical responses to cytochalasin D.
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The reactions of XTH-2 cells (line derived from Xenopus laevis tadpole hearts) to cytochalasin D (CD) were followed using scanning acoustic microscopy (SAM) at 0.9 GHz, fluorescence and electron microscopy. The first reaction to CD which can be detected by SAM is a loss of image contrast, indicating a decrease in acoustic impedance of about 30%. Based on structural changes revealed by staining of actin with TRITC-phalloidin, and taking theoretical considerations into account, a relationship between impedance decrease and tension in the actin fibrillar system is deduced.
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Species referenced: Xenopus laevis
Genes referenced: actl6a