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XB-ART-19926
Pflugers Arch 1995 Apr 01;4296:820-4. doi: 10.1007/bf00374806.
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Influence of extracellular Ca2+ on endogenous Cl- channels in Xenopus oocytes.

Weber WM , Liebold KM , Reifarth FW , Uhr U , Clauss W .


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Removal of Ca2+ from the external bath solution evoked marked depolarization and large currents (up to several microamperes) in voltage-clamped defolliculated oocytes of Xenopus laevis. The resulting current was not carried by a cation influx but was due to a huge Cl- efflux, which could be strongly inhibited by the Cl- channel blockers flufenamic acid and niflumic acid. Removal of Mg2+ or Ba2+ from the solutions had the same effects as removing Ca2+. The reversal potential of -12 mV also indicated that Cl- channels were responsible for the large currents. Patch-clamp studies revealed a single-channel slope conductance of 90 pS. During oocyte maturation these channels remained active. The half-maximal Ca2+ concentration of about 20 microM showed that quite low doses of extracellular Ca2+ profoundly influence the electrical properties of the oocyte membrane.

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References [+] :
Barish, A transient calcium-dependent chloride current in the immature Xenopus oocyte. 1983, Pubmed, Xenbase