XB-ART-26512
Nature
1989 Sep 07;3416237:33-8. doi: 10.1038/341033a0.
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Interaction between peptide growth factors and homoeobox genes in the establishment of antero-posterior polarity in frog embryos.
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The expression of the Xenopus homoeobox gene xhox3 is an early response to mesoderm induction by peptide growth factors and the level of xhox3 expression marks the antero-posterior character of the induced mesoderm. Different peptide growth factors specify different antero-posterior mesodermal cell fates as seen by the level of xhox3 expression and the capacity to induce specific secondary neural/epidermal structures. These factors and homoeobox genes thus form part of the mechanism necessary for establishing antero-posterior polarity in the frog embryo.
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Species referenced: Xenopus laevis
Genes referenced: evx1