XB-ART-27317
Science
1988 Sep 02;2414870:1223-5.
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Platelet-derived growth factor A chain is maternally encoded in Xenopus embryos.
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Transcription of zygotic genes does not occur in early Xenopus embryos until the mid-blastula transition, 6 to 7 hours after fertilization. Before this time, development is directed by maternal proteins and messenger RNAs stored within the egg. Two different forms of the A chain of platelet-derived growth factor (PDGF) are shown here to be encoded by maternal messenger RNAs. The two forms closely resemble human PDGF; however, the long form contains a hydrophobic region near the carboxyl terminus. The presence of PDGF messenger RNA in the embryo supports the idea that endogenous growth factors act at the earliest stages of embryogenesis.
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Species referenced: Xenopus laevis
Genes referenced: pdgfa