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XB-ART-15612
J Cell Physiol 1998 Feb 01;1742:154-9. doi: 10.1002/(SICI)1097-4652(199802)174:2<154::AID-JCP2>3.0.CO;2-N.
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Ca2+-dependence of the depolarization-inducible Na+ current of Xenopus oocytes.

Bossi E , Centinaio E , Moriondo A , Peres A .


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The role of Ca2+ on the depolarization-induced appearance of a Na+ current in Xenopus oocytes was studied. Oocytes were voltage-clamped and the induction of the Na+ current was tested under various conditions. In oocytes pre-injected with 400 pmol EGTA to increase the intracellular Ca2+ buffering power, the current was significantly reduced. Conversely, when intracellular Ca2+ was made to increase by injecting an analogue of inositol 1,4,5-trisphosphate (3-F InsP3), to cause Ca2+ release from internal stores, the induction of the Na+ current was potentiated. The depolarization-inducible Na+ channels of the Xenopus oocyte membrane appear, therefore, to be Ca2+ sensitive, as well as depolarization-activated.

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