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Dev Biol 2012 Jun 01;3661:2-9. doi: 10.1016/j.ydbio.2011.12.042.
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Development and evolution of the neural crest: an overview.

Bronner ME , LeDouarin NM .

The neural crest is a multipotent and migratory cell type that forms transiently in the developing vertebrate embryo. These cells emerge from the central nervous system, migrate extensively and give rise to diverse cell lineages including melanocytes, craniofacial cartilage and bone, peripheral and enteric neurons and glia, and smooth muscle. A vertebrate innovation, the gene regulatory network underlying neural crest formation appears to be highly conserved, even to the base of vertebrates. Here, we present an overview of important concepts in the neural crest field dating from its discovery 150 years ago to open questions that will motivate future research.

PubMed ID: 22230617
PMC ID: PMC3351559
Article link: Dev Biol
Grant support: [+]

References [+] :
Ayer-Le Lievre, The early development of cranial sensory ganglia and the potentialities of their component cells studied in quail-chick chimeras. 1983, Pubmed