XB-ART-52296
Dongwuxue Yanjiu
2016 Jul 18;374:237-45. doi: 10.13918/j.issn.2095-8137.2016.4.237.
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Research proceedings on amphibian model organisms.
Liu LS
,
Zhao LY
,
Wang SH
,
Jiang JP
.
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Model organisms have long been important in biology and medicine due to their specific characteristics. Amphibians, especially Xenopus, play key roles in answering fundamental questions on developmental biology, regeneration, genetics, and toxicology due to their large and abundant eggs, as well as their versatile embryos, which can be readily manipulated and developed in vivo. Furthermore, amphibians have also proven to be of considerable benefit in human disease research due to their conserved cellular developmental and genomic organization. This review gives a brief introduction on the progress and limitations of these animal models in biology and human disease research, and discusses the potential and challenge of Microhyla fissipes as a new model organism.
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References [+] :
Abu-Daya,
Absence of heartbeat in the Xenopus tropicalis mutation muzak is caused by a nonsense mutation in cardiac myosin myh6.
2009, Pubmed,
Xenbase
Abu-Daya, Absence of heartbeat in the Xenopus tropicalis mutation muzak is caused by a nonsense mutation in cardiac myosin myh6. 2009, Pubmed , Xenbase
Amir, Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. 1999, Pubmed
Barribeau, Major histocompatibility complex based resistance to a common bacterial pathogen of amphibians. 2008, Pubmed , Xenbase
Beck, Beyond early development: Xenopus as an emerging model for the study of regenerative mechanisms. 2009, Pubmed , Xenbase
Berg, Xenopus tropicalis as a test system for developmental and reproductive toxicity. 2009, Pubmed , Xenbase
Bevan, Environmental estrogens alter early development in Xenopus laevis. 2003, Pubmed , Xenbase
Bonnard, Mutations in IRX5 impair craniofacial development and germ cell migration via SDF1. 2012, Pubmed , Xenbase
Brockes, Amphibian limb regeneration: rebuilding a complex structure. 1997, Pubmed
Chida, Phylogenetic and developmental study of CD4, CD8 α and β T cell co-receptor homologs in two amphibian species, Xenopus tropicalis and Xenopus laevis. 2011, Pubmed , Xenbase
Chien, A Wnt survival guide: from flies to human disease. 2009, Pubmed
Ciau-Uitz, VEGFA-dependent and -independent pathways synergise to drive Scl expression and initiate programming of the blood stem cell lineage in Xenopus. 2013, Pubmed , Xenbase
DENT, Limb regeneration in larvae and metamorphosing individuals of the South African clawed toad. 1962, Pubmed
Damjanovski, Role of ECM remodeling in thyroid hormone-dependent apoptosis during anuran metamorphosis. 2000, Pubmed , Xenbase
Delaune, Neural induction in Xenopus requires early FGF signalling in addition to BMP inhibition. 2005, Pubmed , Xenbase
Dumpert, Platanna (Xenopus laevis) as a test organism for determining the embryotoxic effects of environmental chemicals. 1984, Pubmed , Xenbase
Fields, Cell biology. Whither model organism research? 2005, Pubmed
Fites, Inhibition of local immune responses by the frog-killing fungus Batrachochytrium dendrobatidis. 2014, Pubmed , Xenbase
Fites, The invasive chytrid fungus of amphibians paralyzes lymphocyte responses. 2013, Pubmed , Xenbase
GURDON, Sexually mature individuals of Xenopus laevis from the transplantation of single somatic nuclei. 1958, Pubmed , Xenbase
Geschwind, Advances in autism. 2009, Pubmed
Gotoh, Regulatory pathways coordinating cell cycle progression in early Xenopus development. 2011, Pubmed , Xenbase
Grant, The Xenopus ORFeome: A resource that enables functional genomics. 2015, Pubmed , Xenbase
Guo, Efficient RNA/Cas9-mediated genome editing in Xenopus tropicalis. 2014, Pubmed , Xenbase
Hardwick, An oncologist׳s friend: How Xenopus contributes to cancer research. 2015, Pubmed , Xenbase
Harland, Xenopus research: metamorphosed by genetics and genomics. 2011, Pubmed , Xenbase
Hartley, Transgenic Xenopus embryos reveal that anterior neural development requires continued suppression of BMP signaling after gastrulation. 2001, Pubmed , Xenbase
Heimeier, Studies on Xenopus laevis intestine reveal biological pathways underlying vertebrate gut adaptation from embryo to adult. 2010, Pubmed , Xenbase
Hellsten, The genome of the Western clawed frog Xenopus tropicalis. 2010, Pubmed , Xenbase
Hemmati-Brivanlou, Inhibition of activin receptor signaling promotes neuralization in Xenopus. 1994, Pubmed , Xenbase
Hirsch, Xenopus tropicalis transgenic lines and their use in the study of embryonic induction. 2002, Pubmed , Xenbase
Hirsch, Xenopus, the next generation: X. tropicalis genetics and genomics. 2002, Pubmed , Xenbase
Ho, TGF-beta signaling is required for multiple processes during Xenopus tail regeneration. 2008, Pubmed , Xenbase
Ishizuya-Oka, Thyroid hormone-regulated Wnt5a/Ror2 signaling is essential for dedifferentiation of larval epithelial cells into adult stem cells in the Xenopus laevis intestine. 2014, Pubmed , Xenbase
Khoudoli, Temporal profiling of the chromatin proteome reveals system-wide responses to replication inhibition. 2008, Pubmed , Xenbase
Kinoshita, Creating frog heart as an organ: in vitro-induced heart functions as a circulatory organ in vivo. 2010, Pubmed , Xenbase
LaBonne, Modeling human development and disease in Xenopus. Preface. 2015, Pubmed , Xenbase
Lamb, Neural induction by the secreted polypeptide noggin. 1993, Pubmed , Xenbase
Lee-Liu, Genome-wide expression profile of the response to spinal cord injury in Xenopus laevis reveals extensive differences between regenerative and non-regenerative stages. 2014, Pubmed , Xenbase
Lei, Efficient targeted gene disruption in Xenopus embryos using engineered transcription activator-like effector nucleases (TALENs). 2012, Pubmed , Xenbase
Li, Requirement for phosphorylation of cyclin B1 for Xenopus oocyte maturation. 1995, Pubmed , Xenbase
Lin, Requirement for Wnt and FGF signaling in Xenopus tadpole tail regeneration. 2008, Pubmed , Xenbase
Luca, Esculentin(1-21), an amphibian skin membrane-active peptide with potent activity on both planktonic and biofilm cells of the bacterial pathogen Pseudomonas aeruginosa. 2013, Pubmed
Makanae, Cooperative inputs of Bmp and Fgf signaling induce tail regeneration in urodele amphibians. 2016, Pubmed
Marshak, Cell-autonomous alterations in dendritic arbor morphology and connectivity induced by overexpression of MeCP2 in Xenopus central neurons in vivo. 2012, Pubmed , Xenbase
Morrison, Salamander limb regeneration involves the activation of a multipotent skeletal muscle satellite cell population. 2006, Pubmed
Nieuwkoop, Inductive interactions in early amphibian development and their general nature. 1985, Pubmed , Xenbase
Odelberg, Cellular plasticity in vertebrate regeneration. 2005, Pubmed
Ogino, Convergence of a head-field selector Otx2 and Notch signaling: a mechanism for lens specification. 2008, Pubmed , Xenbase
Pratt, Modeling human neurodevelopmental disorders in the Xenopus tadpole: from mechanisms to therapeutic targets. 2013, Pubmed , Xenbase
Pyron, A large-scale phylogeny of Amphibia including over 2800 species, and a revised classification of extant frogs, salamanders, and caecilians. 2011, Pubmed
Robert, Comparative and developmental study of the immune system in Xenopus. 2009, Pubmed , Xenbase
Saka, Spatial and temporal patterns of cell division during early Xenopus embryogenesis. 2001, Pubmed , Xenbase
Salanga, Xenopus as a Model for GI/Pancreas Disease. 2015, Pubmed , Xenbase
Saria, Short term exposure to multi-walled carbon nanotubes induce oxidative stress and DNA damage in Xenopus laevis tadpoles. 2014, Pubmed , Xenbase
Sasai, Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus. 1995, Pubmed , Xenbase
Satoh, Regeneration inducers in limb regeneration. 2015, Pubmed , Xenbase
Savage, Conservation and divergence in the frog immunome: pyrosequencing and de novo assembly of immune tissue transcriptomes. 2014, Pubmed
Schmitt, Engineering Xenopus embryos for phenotypic drug discovery screening. 2014, Pubmed , Xenbase
Sitaram, Structure-function relationship studies on the frog skin antimicrobial peptide tigerinin 1: design of analogs with improved activity and their action on clinical bacterial isolates. 2002, Pubmed
Slack, Cellular and molecular mechanisms of regeneration in Xenopus. 2004, Pubmed , Xenbase
Tanaka, The cellular basis for animal regeneration. 2011, Pubmed , Xenbase
Tata, Metamorphosis: an exquisite model for hormonal regulation of post-embryonic development. 1996, Pubmed , Xenbase
Vernon, The cdk inhibitor p27Xic1 is required for differentiation of primary neurones in Xenopus. 2003, Pubmed , Xenbase
Whitman, Smads and early developmental signaling by the TGFbeta superfamily. 1998, Pubmed
Woodland, Some studies on early embryonic development relevant to the study of cancer. 1974, Pubmed , Xenbase
Xiang, Host-derived, pore-forming toxin-like protein and trefoil factor complex protects the host against microbial infection. 2014, Pubmed
Xu, The chemistry and biological activities of peptides from amphibian skin secretions. 2015, Pubmed , Xenbase
Yang, Beta-catenin/Tcf-regulated transcription prior to the midblastula transition. 2002, Pubmed , Xenbase
Ymlahi-Ouazzani, Reduced levels of survival motor neuron protein leads to aberrant motoneuron growth in a Xenopus model of muscular atrophy. 2010, Pubmed , Xenbase
Yokoyama, Mesenchyme with fgf-10 expression is responsible for regenerative capacity in Xenopus limb buds. 2000, Pubmed , Xenbase
Young, Efficient targeted gene disruption in the soma and germ line of the frog Xenopus tropicalis using engineered zinc-finger nucleases. 2011, Pubmed , Xenbase
Yun, Sustained ERK activation underlies reprogramming in regeneration-competent salamander cells and distinguishes them from their mammalian counterparts. 2014, Pubmed
Zhao, Transcriptome profiles of metamorphosis in the ornamented pygmy frog Microhyla fissipes clarify the functions of thyroid hormone receptors in metamorphosis. 2016, Pubmed , Xenbase
Zhao, Comprehensive transcriptome profiling and functional analysis of the frog (Bombina maxima) immune system. 2014, Pubmed