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PLoS One 2011 Jan 01;67:e22569. doi: 10.1371/journal.pone.0022569.
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Expression of Transposable Elements in Neural Tissues during Xenopus Development.

Faunes F , Sanchez N , Moreno M , Olivares GH , Lee-Liu D , Almonacid L , Slater AW , Norambuena T , Taft RJ , Mattick JS , Melo F , Larrain J .

Transposable elements comprise a large proportion of animal genomes. Transposons can have detrimental effects on genome stability but also offer positive roles for genome evolution and gene expression regulation. Proper balance of the positive and deleterious effects of transposons is crucial for cell homeostasis and requires a mechanism that tightly regulates their expression. Herein we describe the expression of DNA transposons of the Tc1/mariner superfamily during Xenopus development. Sense and antisense transcripts containing complete Tc1-2_Xt were detected in Xenopus embryos. Both transcripts were found in zygotic stages and were mainly localized in Spemann's organizer and neural tissues. In addition, the Tc1-like elements Eagle, Froggy, Jumpy, Maya, Xeminos and TXr were also expressed in zygotic stages but not oocytes in X. tropicalis. Interestingly, although Tc1-2_Xt transcripts were not detected in Xenopus laevis embryos, transcripts from other two Tc1-like elements (TXr and TXz) presented a similar temporal and spatial pattern during X. laevis development. Deep sequencing analysis of Xenopus tropicalis gastrulae showed that PIWI-interacting RNAs (piRNAs) are specifically derived from several Tc1-like elements. The localized expression of Tc1-like elements in neural tissues suggests that they could play a role during the development of the Xenopus nervous system.

PubMed ID: 21818339
PMC ID: PMC3144230
Article link: PLoS One

Species referenced: Xenopus tropicalis Xenopus laevis
Genes referenced: chrd odc1 piwil1 szl tcim

GEO Series: GSE30067: Xenbase,  NCBI

Article Images: [+] show captions
References [+] :
Amaral, The eukaryotic genome as an RNA machine. 2008, Pubmed